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## PBFTPK models |

Τhe models are based on the work:

P. Chryssafidis, A.A. Tsekouras, P. Macheras, Re-writing
Oral Pharmacokinetics Using Physiologically Based Finite
Time Pharmacokinetic (PBFTPK) Models, Pharmaceutical
Research (2022) 39:691–701.
[Link]

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Short description of Physiologically based finite
time pharmacokinetic (PBFTPK) models
**

For drugs following linear disposition kinetics, the
term p-PBFTPK-m is used, where p is the number of the
successive input rates (p = 1, 2, 3, 4) and m the number of
the compartments (m = 1,2) F is the bioavailable
fraction of dose D, Vd is the volume of distribution and
ka, kel are the absorption and elimination first-order
rate constants, respectively.