In vivo nanoparticle delivery general model |
Τhe model is based on the work:
Jamie L.Y. Wua, Benjamin P. Stordy, Luan N.M. Nguyen,
Christopher P. Deutschman, Warren C.W. Chan, A proposed
mathematical description of in vivo nanoparticle
delivery Advanced Drug Delivery Reviews 189 (2022)
114520 /p>
[Link]
Short description of the in vivo nanoparticle delivery
The compartmental kinetics model and rate equations for targeted delivery.
These compartments include the administration site, target cell vicinity, target cell interior, and off-target sites.
Biological processes that distribute nanoparticles between these compartments are expressed as rate constants.
They are categorized as transport towards target cell vicinity (kTTC), transport into the target cell (kITC), clearance (kC),
and transport away from target cells (kATC). Negative rate constants represent processes that move nanoparticles
out of a compartment, whereas positive rate constants represent processes that move nanoparticles into a compartment.
*This project has received funding from the European Union EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions under grant agreement nº 101008099