This is a predictive model for the assessment of the biological response (cellular association, which can include both internalized NPs and those attached to the cell surface) of surface-modified gold NPs, based on their physicochemical properties and protein corona fingerprints, utilizing a dataset of 105 unique NPs. Cellular association was chosen as the end-point for the original experimental study due to its relevance to inflammatory responses, biodistribution, and toxicity in vivo.

* w/ serum Z-Average Hydrodynamic Diameter
** w/ serum Zeta Potential (mV)
*** w/ serum (AU) Localized Surface Plasmon Resonance (LSPR) index