NanoCommons Risk Assessment Tool
The workflow is a combination of nanoinformatics tools available through the NanoCommons computational infrastructure. This web application, hosted and implemented within Enalos Cloud Platform, estimates the risk of triggering AOP 173 (Lung Fibrosis) in mice due to exposure to 20nm TiO2 engineered nanoparticles.
External exposure: Four different exposure scenarios have been simulated using the GUIDENano tool. The user can alternatively enter a custom-made scenario.
Internal exposure: Concentration-time profiles for mice are simulated using a PBPK model which has been developed and implemented in the Jaqpot platform. A plot depicting the mass-time profile in the lung is automatically generated.
Risk assessment: Is performed by comparing the predicted distribution of TiO2 concentration in the lungs with Points of Departure (POD) that have been computed using a gene expression analysis workflow. The user can select the POD of interest among different pathways involved in AOP173 or the median value that defines the POD of the AOP and short term (1 day) or long term (28 days) effects.
*This work project has received funding from European Union Horizon 2020 Programme (H2020) via NanoCommons research infrastructure project under grant agreement nº 731032