SABYDOMA’s main objective is to develop a new methodology to address the Safety by Design (SbD) challenge as a Control System Problem. Its technological solution is coupling screening to design, i.e. the screening at the point of production feeds back to modify the design of nanomaterials. SABYDOMA will use system control and optimisation theory including the Model Predictive Control (MPC) philosophy, binding SbD from laboratory innovation to the industrial production line and from decision making processes to project governance.